Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as Food-Grade Nanovehicles for Hydrophobic Nutraceuticals or Bioactives

Although solid lipid nanoparticles (SLNs) and nanostructured carriers (NLCs) have been successfully used as drug delivery systems for about 30 years, the usage of these food-grade nanovehicles nutraceuticals or bioactive compounds has been, relatively speaking, scarcely investigated. With fast-increasing interest in incorporation a wide range bioactives food formulations, well health awareness consumers, there renewed urge development food-compatible SLNs and/or NLCs improving water dispersibility, stability, bioavailability, bioactivities many lipophilic poorly soluble bioactives. In this review, NLCs, their utilization nanosized hydrophobic nutraceuticals, was comprehensively reviewed. First, structural composition preparation methods were simply summarized. Next, some key issues such oral nanovehicles, e.g., release bioactives, oxidative digestion absorption, intestinal transport, critically discussed. Then, recent advances encapsulation different liposoluble The performance curcuminoids (and curcumin particular) also highlighted. Lastly, strategies to improve bioavailability loaded presented. review will be relevant, providing state-of-the-art knowledge lipid-based stability nutraceuticals.